产品货号：
Z24008
中文名称：
POLK抗体
英文名称：
Anti-POLK Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-POLK Antibody |
| 指标别名 | goat Anti-POLK;goat Anti-DNA polymerase kappa;DINB homolog 1 (E.coli);DINB protein;DINB1;DINP;DNA damage inducible protein b;POLQ |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | POLK |
| 抗体来源 | Goat |
| 抗体类型 | IgG |
| 免疫原 | This affinity-purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 817-830 of Human POLK (polymerase (DNA directed) kappa). |
| 计算分子量 | 99kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against human POLK protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest reactivity with this protein from human,chimpanzee and orangutan based on 100% homology for the immunogen sequence.Cross-reactivity with POLK protein from mouse is expected,as this sequence is highly homologous in human and mouse.Expect reactivity with multiple splice variants of this protein.Cross-reactivity with POLK homologues from other sources has not been determined. |
| 浓度 | 1.4mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | POLK (also known as DNA polymerase kappa,DINB protein and DINP) is involved in DNA repair.POLK plays an important role in translesion synthesis,where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.Depending on the context,it inserts the correct base,but causes frequent base transitions,transversions and frameshifts.POLK lacks 3'-5' proofreading exonuclease activity.POLK is a nuclear protein that binds to REV1L and PCNA.POLK is detected throughout the nucleus and at replication foci.Multiple alternative splice variants have been detected for this protein.POLK is found at low levels in testis,spleen,prostate and ovary and at very low levels in kidney,colon,brain,heart,liver,lung,placenta,pancreas and peripheral blood leukocytes. |
| Uniprot ID | Q9UBT6 |
| 基因名全称 | DNA polymerase kappa |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 WB:1:500 - 1:3,000 |
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